Genetic research: Hope for everyone affected by dementia

Researchers have been working tirelessly over the last two decades to understand the genetics of dementia. Find out how this fast-moving area of research could be life-changing for people like Daniel Bradbury, who was diagnosed with a rare form of dementia, aged 30.

The genetics of dementia might be complex, but researchers across the globe agree that they could hold the key to a cure. 

Although it is very rare for dementia to be inherited, research has found other genes that influence our risk of developing the condition. These genes provide researchers with clues to identify new targets for drugs and other therapies that might slow down or stop dementia in its tracks.

Daniel and Jordan

Daniel Bradbury, 31, was diagnosed with a rare form of Alzheimer’s caused by a mutation in the gene called PSEN1.

He inherited the gene from his father, Adrian, who died from the condition himself aged just 36. 

‘Treatments are great, but for me, as somebody who is watching their partner live with the condition and manage it every day, nothing short of a cure will do.’

- Daniel’s wife, Jordan Bradbury

There is a 50 per cent chance that Daniel and Jordan's two-year-old twins, Lola and Jasper (pictured below), have inherited the PSEN1 gene. Jordan is worried not only for her husband, but also for her children.

Daniel Bradbury with his wife and family

Jordan believes that if something doesn’t change in the development of dementia treatment, history will simply repeat itself. 

‘I'm going to be caring for my children who will have Alzheimer's in their early thirties. I could lose my entire family unit before I retire. That for me is a very scary feeling, a very scary reality. I want there to be something available for my children should they need it.’

- Jordan Bradbury

Better understanding

Ten years ago, dementia researchers only knew about one gene – ApoE – that is known to play a role in our risk of Alzheimer’s disease. 

Now, thanks to the families affected by dementia who have put themselves forward for research, we know so much more. 

Today, we know of over 25 genes involved in risk for Alzheimer’s disease, as well as specific rare gene mutations that cause Alzheimer’s disease. 

Invaluable projects like the 100,000 Genomes Project mean we also understand much more about how these genes work together to cause dementia. 

Learning from other conditions

Gene therapies work by using ‘molecular scissors’ to remove or silence specific genes we know are involved in causing a condition.

In recent years we’ve seen astonishing results in gene therapy trials to treat incurable debilitating neurological illnesses including Spinal Muscular Atrophy and Huntington’s disease. 

Alzheimer’s Society researcher Professor Sarah Tabrizi has shown in a phase 2 trial that gene therapy can reduce levels of the toxic Huntington protein that causes Huntington’s disease. The next step will be to test this therapy on a larger group of people with Huntington’s disease to see if the treatment can prevent the disease from progressing.

Dementia researchers are watching as these results unfold. They are learning from these breakthroughs, bringing us closer than ever before to seeing a gene therapy for dementia.

At the UK Dementia Research Institute, researchers such as Professor Adrian Isaacs are already using similar approaches to target a faulty gene that causes frontotemporal dementia.

What’s on the horizon for dementia research? 

It’s vital that we make the most of this new and ever-growing knowledge of the genetics behind dementia. 

Alzheimer’s Society’s Head of Research, Dr James Pickett, said:

‘We’re at a tipping point for dementia gene therapy. There are lots of different piece of the puzzle coming together. We’ve got all of this genetic knowledge, like cancer researchers did 30 years ago, and now we’re investing in understanding and exploiting it.’

But with more Government investment, the field could really take off. In 30 years’ time, we hope we can prevent dementia before there are any symptoms. 

In Alzheimer’s disease, researchers are using techniques to stop a toxic protein in the brain (tau) forming, by disrupting the way our genetic code make these proteins.

Researchers at University College London are currently recruiting people with Alzheimer’s disease to this trial.

Take part in research

Register with Join Dementia Research, an online platform that matches you to studies taking place in your area. Alternatively, or call our National Dementia Helpline to make an enquiry.

Join Dementia Research Enquire by phone
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8 comments

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How can me and my sister take part in research? Our mum was diagnosed in her early 60’s and now doesn’t know who we are. We live in fear that we will end up with this horrible disease x

Hi Leanne

Thanks for getting in touch. There are lots of different ways for you and your sister to get involved in research.

If you’d like to take part in research studies, you might like to register with Join Dementia Research. It's an online platform that can match you to studies in your area. Register at https://www.joindementiaresearch.nihr.ac.uk/

Alternatively, you can call our National Dementia Helpline to register on 0300 222 11 22 (www.alzheimers.org.uk/helpline).

Our Helpline advisers are also available to talk about any concerns you or your sister may have about your mum or dementia.

My mind has been affected for over a year now. I don’t know the, medical name of my problem. I did find a term of Brain Fog on the internet. I talked to my family doctor about it and used the term Brain Fog. I have found out that Brain Fog is not a Medical Term and he has been slow to discuss my situation or recommend any action to take. I searched the internet and found that low blood to the brain could be my problem and there were blood test that might show something. I told me doctor about it and he ordered the tests and I passed all of them. I had seen a heart surgeon about the blockage in my neck. He said my blockage was not enough for a operation. I saw a heart specialist who said I had a healthy heart. I have had 2 appointments with a Neurologist who has found nothing but gave me a new appointment date a year after the last one.
I have had x-rays or scans of my brain. All normal. Any time I find something new that might help me, my family doctor is very cooperative in getting it looked into. Finally, my family doctor did on his own, give me two prescriptions. One made me too nervous to take and the other is a tranquilizer type medicine and is supposed to help my depression, which I do not take.
I am not happy with my situation but I do not believe my unhappiness means I am depressed and need to be tranquilized. I do think there are some drunks and people taking too many drugs need it. My balance can be bad and it affects my walking There are times that by right foot wants to turn right and doesn’t tell my left foot about it and they collide and I almost fall.
My mental moods can have a few moods from Love to Anger. Other than that, I am 88 years old and looking to be 89.

Is this only in the UK? I’m very interested, but live in the US.

Hi Deb
Thank you for getting in touch.
The trial mentioned in this blog is taking place in the UK and a number of other countries, but there currently isn’t a centre in the USA.
If you are interested in taking part in research, we’d recommend speaking to your doctor. You can find out about research studies happening in your area at https://clinicaltrials.gov/
We hope this helps.

dont know if i should laugh or cry its to late for my wife she barely knows me now

Hi George
We’re very sorry to hear you’re going through such a difficult time at the moment.
If you would like to talk to someone, please call our National Dementia Helpline on 0300 222 11 22 (www.alzheimers.org.uk/helpline).
Our Helpline advisers are available for a chat. They can provide information, advice and support over the phone, which you may find helpful.
Alternatively, our online community – Talking Point – is a place for people affected by dementia to share their experiences and get advice (https://www.alzheimers.org.uk/get-support/talking-point-our-online-comm…).
Wishing you all the best, George.

I have been involved in a few small research projects....nothing too intrusive and nothing to do with finding out if I have the disease, as at this point I would rather not know. Just mention this to encourage others who may not realise there is a wide range of projects being undertaken that they could become involved in

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