Corticobasal degeneration (CBD)

Corticobasal degeneration (CBD) is a rare disease in which parts of the brain become damaged and begin to shrink.

What is the effect of corticobasal degeneration (CBD) to the brain?

The outer layer of the brain, known as the cortex, and deep parts of the brain, called the basal ganglia, are both affected. It is not yet known what causes CBD but producing too much of an abnormal form of a protein called tau is thought to play a role.

The disease usually affects people between the ages of 60 and 80.

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What are the symptoms of CBD?

The first symptoms that people with CBD experience are problems with movement, such as stiffness and jerkiness in one or more of their limbs and a failure to control hand movement on one side (known as 'alien hand syndrome').

As the disease progresses, these problems will often spread to other limbs. Many people experience symptoms of dementia, including problems with memory and thinking.

A small proportion of people with frontotemporal dementia also develop CBD as an 'overlapping' condition. Other symptoms of CBD include loss of balance and co-ordination, and difficulties speaking and swallowing.

What treatment is available for CBD?

Currently, there is no cure or treatment available to slow the progression of CBD, but drugs may help some symptoms and physiotherapy, occupational therapy and speech and language therapy may be beneficial. On average, people live for around eight years after their symptoms first appear.

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