New method developed for delivering drugs to the brain, says study

Researchers at Oxford University injected exosomes - tiny particles naturally released by cells - into the blood of mice. They found that for the first time, using this 'natural' system they were able to transfer potential new drugs across the normally impermeable blood-brain barrier and into the brain.

This new technology was also found to reduce the production of the enzyme BACE1, which helps produce the plaques in the brain in Alzheimer's disease.

Alzheimer's Society comment:

'In this exciting study, researchers may have overcome a major barrier to the delivery of potential new drugs for many neurological diseases including Alzheimer's. The blood-brain barrier protects the brain from harmful chemicals, but also makes it difficult for drugs to reach the target cells. If this delivery method proves safe in humans, then we may see more effective drugs being made available for people with Alzheimer's in the future.'

'More research is now needed to see if this method would be effective for people with Alzheimer's. Dementia research is desperately underfunded. To make the breakthroughs we need, we must invest now.'

Dr Susanne Sorensen
Head of Research
Alzheimer's Society

-Ends -

Research reference:  Alvarez-Erviti, Seow, Yin et al, 'Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes', Nature Biotechnology, 20 March 2011.

Notes to editors:

• One in three people over 65 will die with dementia
• Alzheimer's Society research shows that 750,000 people in the UK have a form of dementia, more than half have Alzheimer's disease. In just 15 years a million people will be living with dementia. This will soar to 1.7 million people by 2051
• Alzheimer's Society champions the rights of people living with dementia and the millions of people who care for them
• Alzheimer's Society works in England, Wales and Northern Ireland
• Alzheimer's Society supports people to live well with dementia today and funds research to find a cure for tomorrow. We rely on voluntary donations to continue our vital work. You can donate now by calling 0845 306 0898 or visiting alzheimers.org.uk
  
• Alzheimer's Society provides a National Dementia Helpline, the number is 0845 300 0336 or visit alzheimers.org.uk