Newer antipsychotic drugs could increase the risk of dangerous blood clots, research claims

This large and important study adds to the growing body of evidence which suggests antipsychotic drugs increase the risk of deep vein thrombosis and pulmonary embolism, and adds significantly to understanding of the serious detrimental effects of antipsychotics to the health of people with dementia. Researchers from the University of Nottingham and Nottinghamshire County Teaching Primary Care Trust studied 25,532 eligible cases (15,975 with deep vein thrombosis and 9,557 with pulmonary embolism) recorded between 1996 and 2007 in people aged between 16 and 100.

Alzheimer's Society comment:

'Alzheimer's Society believes, beyond a shadow of a doubt that antipsychotic drugs should only ever be used as a last resort for people with dementia.'

'The massive over-prescription of antipsychotics to people with dementia leads to an estimated 1,800 deaths a year - this must end. These drugs double the risk of death, triple the risk of stroke and accelerate cognitive decline. The drugs also have a profound effect on quality of life, leaving people heavily sedated.'

'Training staff in dementia care can increase their understanding of the condition and eliminate the need for antipsychotics. Training must be made an immediate priority. It also is of paramount importance to develop safe alternative treatments for distressing behavioural symptoms in people with dementia.'

Professor Clive Ballard
Director of Research
Alzheimer's Society

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Notes to editors:

• One in three people over 65 will die with dementia
• Alzheimer's Society research shows that 750,000 people in the UK have a form of dementia, more than half have Alzheimer's disease. In just 15 years a million people will be living with dementia. This will soar to 1.7 million people by 2051
• Alzheimer's Society champions the rights of people living with dementia and the millions of people who care for them. 
• Alzheimer's Society works in England, Wales and Northern Ireland
• Alzheimer's Society supports people to live well with dementia today and funds research to find a cure for tomorrow. We rely on voluntary donations to continue our vital work. You can donate now by calling 0845 306 0898 or visiting alzheimers.org.uk
  
• Alzheimer's Society provides a National Dementia Helpline, the number is 0845 300 0336 or visit alzheimers.org.uk