Debating the success of Alzheimer’s research

The feature questions why so many trials are failing at the phase 3 clinical trial stage and asks whether the animal models used prior to this are the most effective way to test the drugs. It also suggests treatments should perhaps start to focus more on the changes in the brain that happen before symptoms like memory loss start to appear. However, it notes that these are difficult to replicate in animal models.

Alzheimer's Society comment:

'Scientific research is essential in the search for a cure and treatments for Alzheimer's disease and we must not be too disheartened that many drug trials fall at the final hurdle. The fact only one in five clinical trials across all diseases will be successful highlights the need for more investment so we can defeat dementia.'

'Every day scientists are learning more about the early stages of Alzheimer's disease and this is an important area for further study and development. '

Dr Susanne Sorensen

Head of Research
Alzheimer's Society

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Notes to editors:

• One in three people over 65 will die with dementia.
• Alzheimer's Society research shows that 750,000 people in the UK have a form of dementia, more than half have Alzheimer's disease. In just 15 years a million people will be living with dementia. This will soar to 1.7 million people by 2051.
• Alzheimer's Society champions the rights of people living with dementia and the millions of people who care for them.
• Alzheimer's Society works in England, Wales and Northern Ireland.
• Alzheimer's Society supports people to live well with dementia today and funds research to find a cure for tomorrow. We rely on voluntary donations to continue our vital work. You can donate now by calling 0845 306 0898 or visiting alzheimers.org.uk
  
• Alzheimer's Society provides a National Dementia Helpline, the number is 0845 300 0336 or visit alzheimers.org.uk