Alzheimer's gene linked to cognitive impairment in mid-life

Scientists carried out genetic tests and analysed the memory and learning of 726 middle-aged people without Alzheimer's disease. Results showed that people with a particular version (LPT) of the TOMM40 gene did worse on tests of memory and learning. People with this gene were also more likely to have the Alzheimer's gene, ApoE4. A further smaller study also showed that people with the new gene had less brain volume in areas of the brain associated with Alzheimer's disease.

Alzheimer's Society comment:

'These interesting preliminary studies have shown a gene linked to Alzheimer's also alters cognitive function in mid-life. Memory problems linked to the gene are by no means a predictor of Alzheimer's in later life. However it could represent a small but important risk. A better understanding of how genetic and other risk factors lead to cognitive impairment in mid-life will help researchers target prevention of dementia more effectively.'

'The number of people with dementia is expected to reach a million within a generation yet dementia research is dramatically underfunded. If we want to see the same advancements in dementia as we have for cancer we must invest more. '

Professor Clive Ballard
Director of Research
Alzheimer's Society

- Ends -

Study reference: 'TOMM40 is assoiated with grey matter volume in middle-aged persons with APOE3 genotype' by Sterling Johnson et al.

Notes to editors:

• For spokespeople and case studies contact the Alzheimer's Society press office on 0207 423 3595.
• ICAD is the world's leading forum on dementia research. Run by Alzheimer's Association, it will this year be taking place in Hawaii from Sunday 11 July to Thursday 15 July.
• One in three people over 65 will die with dementia.
• Alzheimer's Society research shows that 750,000 people in the UK have a form of dementia, more than half have Alzheimer's disease. In just 15 years a million people will be living with dementia. This will soar to 1.7 million people by 2051.
• Alzheimer's Society champions the rights of people living with dementia and the millions of people who care for them.
• Alzheimer's Society works in England, Wales and Northern Ireland.
• Alzheimer's Society supports people to live well with dementia today and funds research to find a cure for tomorrow. We rely on voluntary donations to continue our vital work. You can donate now by calling 0845 306 0898 or visiting alzheimers.org.uk
  
• Alzheimer's Society provides a National Dementia Helpline, the number is 0845 300 0336 or visit alzheimers.org.uk