Delayed ageing linked to Alzheimer’s in mice

The scientists who undertook the study in the US suggest this could lead to development of new drug treatments in Alzheimer's disease.

The study found that a reduction in a specific signalling cascade, known as Insulin-Insulin Growth Factor (IGF) signalling might enhance activity in brain mechanisms that could protect against Alzheimer's. The mice, genetically modified to develop Alzheimer's disease, had less inflammation in the brain when this signalling was reduced.

Susanne Sorensen, Head of Research, Alzheimer's Society says,

'This interesting study identifies new avenues for drug development that target this process associated with ageing. Drugs take years to develop and new treatments based on this discovery may be a long way from hitting pharmacy shelves. Dementia research is desperately underfunded and without investment new treatments will not become available. One million people will develop dementia in the next 10 years. We must act now.'

Dr Susanne Sorensen
Head of Research
Alzheimer's Society

Ends

Notes to editors

• One in three people over 65 will die with dementia
• Alzheimer's Society research shows that 700,000 people in the UK have a form of dementia, more than half have Alzheimer's disease. In less than 20 years nearly a million people will be living with dementia. This will soar to 1.7 million people by 2051.
• Alzheimer's Society champions the rights of people living with dementia and the millions of people who care for them.
• Alzheimer's Society works in England, Wales and Northern Ireland
• Alzheimer's Society needs to raise money to help people live well with dementia today and for research to find a cure for tomorrow. You can donate now by calling 0845 306 0898 or visiting alzheimers.org.uk 
  
• Alzheimer's Society provides a National Dementia Helpline, the number is 0845 300 0336 or visit alzheimers.org.uk