Alzheimer’s Society comment on new research into insulin degrading enzyme ‘Pac-Man’
Published 27 April 2009
It is widely believed that the processes that lead to the generation of beta amyloid plaques are a major factor in causing Alzheimer's disease.
'This new research looks at the activity of one of the enzymes that obstruct the plaque formation. Initial findings are showing that it is possible to kick start this enzyme into activity through its interaction with smaller compounds.
Finding new ways of obstructing the processes that lead to beta amyloid plaques could be a real advantage in the treatment of dementia. However, there is still a long way to go before a 'best' small compound is identified and tested. One million people will develop dementia in the next 10 years yet dementia research is desperately under funded. With more investment in research, dementia can be defeated.'
Dr Susan Sorensen
Head of Research
Alzheimer's Society
Reference: Leissring et al. Small-Molecule Activators of Insulin-Degrading Enzyme Discovered Through High Throughput Compound Screening. PloS ONE, April 2009.
ENDS
Alzheimer's Society
Alzheimer's Society is the leading care and research charity for people with all forms of dementia and their carers. It provides information and education, support for carers, and quality day and home care. It funds medical and scientific research and campaigns for improved health and social services and greater public understanding of dementia.
Alzheimer's Society provides a national help line on 0845 3000 336 and website alzheimers.org.uk. Please include this information in any publication that uses these comments.
For more information contact: Press Office 0207 423 3595 press@alzheimers.org.uk
