Gene research study published in Nature Genetics

'The S0RL1 gene appears to have a key role in late-onset Alzheimer's disease according to a study published in Nature Genetics. The study also reveals a link between the gene and the disposal and recycling of amyloid protein, found in the plaques which appear with Alzheimer's disease. The discovery points to a new area of study for future treatments of the condition.

The study identifies a novel link between the plaques that develop in the brain of people with Alzheimer's disease and the SORL1 gene.

Amyloid protein is at the core of the plaques that develop with Alzheimer's disease and is the popular target for research into Alzheimer's disease. This latest study is exciting because it suggests the SORL1 gene plays a significant role in the recycling and disposal of amyloid protein and late onset Alzheimer's diseases.

The results put the spotlight on an important new area for the development of drugs and treatment targets to tackle Alzheimer's disease. '

Clive Ballard
Director of Research
Alzheimer's Society