Research shows gene mutation could reduce chance of Alzheimer’s disease
Published 11 July 2012
Researchers in Iceland have identified a mutation in the APP gene – a gene usually associated with the development of Alzheimer’s – that actually protects against the disease.
According to the study published in Nature, this particular mutation (A673T) disrupts the production of amyloid-beta protein, a hallmark of Alzheimer's disease.
The researchers studied the cognitive function of a group of people living in care homes; both carriers and non-carriers of the gene mutation. They found that those carrying the mutation experienced less cognitive decline, and were therefore less likely to develop Alzheimer's disease.
Alzheimer's Society comment:
'We know that the development of Alzheimer's can be linked to a combination of genetic and lifestyle factors. We still have a lot to learn about what happens in the brain but this research offers new insight into a gene we already know is linked to the disease.'
'One in three people over 65 will develop dementia. This development offers interesting new information about how our genes might affect our chances of developing Alzheimer's disease. It could also provide a new target for future investigations to find treatments to help people live well with dementia, or even find a cure.'
Dr Anne Corbett
Research Manager
Alzheimer's Society
Research reference: 'A mutation in APP protects against Alzheimer's disease and age-related cognitive decline' by Jonsson et al in Nature
