The DOMINO-AD clinical trial: improving treatment for Alzheimer’s disease
Lead Investigator: Professor Robert Howard
Institution: Institute of Psychiatry, London
Grant type: Project
Duration: 4 years
Amount: £150,000 contribution to a £3m project
Scientific Title: Donepezil and Memantine in Moderate to Severe Alzheimer's Disease: The DOMINO-AD Trial.
There is some evidence to suggest that these drugs may also benefit people who are more severely affected.
It is very important to have reliable evidence about these drugs before campaigning for them to be available to a larger number of patients.
The trial is investigating whether treatment with donepezil for 6 months longer than normal could benefit people with dementia and their carers.
Treatment with a combination of donepezil and memantine is also being compared with donepezil alone.
If conclusive, this trial will lead to better treatment for people with dementia, as well as an improvement in situation for their carers.
Find out more about clinical trials
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Institution: Institute of Psychiatry, London
Grant type: Project
Duration: 4 years
Amount: £150,000 contribution to a £3m project
Scientific Title: Donepezil and Memantine in Moderate to Severe Alzheimer's Disease: The DOMINO-AD Trial.
What do we already know?
Drugs like donepezil (Aricept) are beneficial for people who are mildly or moderately affected by Alzheimer's Disease.There is some evidence to suggest that these drugs may also benefit people who are more severely affected.
It is very important to have reliable evidence about these drugs before campaigning for them to be available to a larger number of patients.
What does this project involve?
DOMINO-AD is a randomised, multi-centre, double blind, placebo-controlled clinical trial involving people with Alzheimer's disease who have reached the moderate to severe stages of the illness.The trial is investigating whether treatment with donepezil for 6 months longer than normal could benefit people with dementia and their carers.
Treatment with a combination of donepezil and memantine is also being compared with donepezil alone.
How will this benefit people with dementia?
When organisations are developing guidance for doctors, they look at the evidence from trials such as this.If conclusive, this trial will lead to better treatment for people with dementia, as well as an improvement in situation for their carers.
Find out more about clinical trials
Back to list of current projects
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